Application of contrast-enhanced magnetic resonance imaging in the assessment of blood-cerebrospinal fluid barrier integrity

VERHEGGEN, I.C.M., W. Freeze, J. de Jong, Jansen, A. Postma, M. van Boxtel, F. Verhey and Backes. The application of contrast-enhanced MRI in the assessment blood-cerebrospinal fluid barrier integrity. Choroid plexus epithelial cells form a that enables active, bidirectional exchange between blood plasma cerebrospinal (CSF), known as blood-CSF (BCSFB). Through its involvement CSF composition, BCSFB maintains homeostasis central nervous system. While relation blood-brain disruption, aging neurodegeneration is extensively studied using MRI, applying this technique to investigate disruption age-related has received little attention. This review provides an overview current status assess permeability. Post-contrast ventricular gadolinium enhancement been used indicate Moreover, new techniques highly sensitive low concentrations CSF, for instance heavily T2-weighted imaging with suppression, seem promising. Also, attempts are made at other contrast agents, such manganese ions or very small superparamagnetic iron oxide particles, be cleared from brain choroid plexus. Advancing developments these could progress